J-104118

J-104118 is a potent and orally active squalene synthase (SQS) inhibitor with an IC50 of 0.52 nM. J-104118 inhibits cholesterol synthesis in mice. J-104118 can be used for cholesterol-lowering research[1].

Product Specifications

CAS Number

[172277-82-6]

UNSPSC

12352005

Target

Farnesyl Transferase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

O=C([C@H](CC(O)=O)CC(N[C@@H](C)[C@@H](CC1=CC=C(C(Cl)=C1)Cl)C2=CC=C(C(F)=C2)C3=CC=CC=C3)=O)O

Molecular Formula

C28H26Cl2FNO5

Molecular Weight

546.41

References & Citations

[1]Iwasawa Y, et al. Synthesis and Biological Activity of J-104,118, a Novel, Potent Inhibitor of Squalene Synthase. Bioorganic & Medicinal Chemistry Letters 1995, 5 (17), 1989–1994.