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5-HT7R antagonist 4

5-HT7R antagonist 4 (Compound 4) is a potent 5-HT7 receptor antagonist (Ki=2.6 nM) with low binding affinity for the 5-HT1A receptor (Ki= 476 nM) . 5-HT7R antagonist 4 is promising for research of neurological diseases[1].

Product Specifications

CAS Number

1386927-90-7

UNSPSC

12352005

Target

5-HT Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

COC1=CC=C(C=C1)C2=CC=CC=C2N3CCNCC3

Molecular Formula

C17H20N2O

Molecular Weight

268.35

References & Citations

[1]Shimoda Y, et al. Synthesis and evaluation of 1-[2- (4-[ (11) C]methoxyphenyl) phenyl]piperazine for imaging of the serotonin 5-HT7 receptor in the rat brain. Bioorg Med Chem. 2013 Sep 1;21 (17) :5316-22.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT1 Receptor;5-HT7 Receptor

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