5-HT7R antagonist 4
5-HT7R antagonist 4 (Compound 4) is a potent 5-HT7 receptor antagonist (Ki=2.6 nM) with low binding affinity for the 5-HT1A receptor (Ki= 476 nM) . 5-HT7R antagonist 4 is promising for research of neurological diseases[1].
Product Specifications
CAS Number
1386927-90-7
UNSPSC
12352005
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
COC1=CC=C(C=C1)C2=CC=CC=C2N3CCNCC3
Molecular Formula
C17H20N2O
Molecular Weight
268.35
References & Citations
[1]Shimoda Y, et al. Synthesis and evaluation of 1-[2- (4-[ (11) C]methoxyphenyl) phenyl]piperazine for imaging of the serotonin 5-HT7 receptor in the rat brain. Bioorg Med Chem. 2013 Sep 1;21 (17) :5316-22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor;5-HT7 Receptor
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