AZT triphosphate (tetraammonium)

AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) tetraammonium is an active triphosphate metabolite of Zidovudine (AZT) . AZT triphosphate tetraammonium exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate tetraammonium also inhibits the DNA polymerase of HBV. AZT triphosphate tetraammonium activates the mitochondria-mediated apoptosis pathway[1][2][3].

Product Specifications

CAS Number

[106060-92-8]

Product Name Alternative

3'-Azido-3'-deoxythymidine-5'-triphosphate (tetraammonium)

UNSPSC

12352005

Target

Apoptosis; DNA/RNA Synthesis; HBV; HIV; Reactive Oxygen Species (ROS)

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-anti-virus

Field of Research

Infection

Purity

99.25

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 70°C)

Smiles

O=C1NC(N([C@@H](C[C@@H]2N=[N+]=[N-])O[C@@H]2COP(OP(O)(OP(O)(O)=O)=O)(O)=O)C=C1C)=O.N.N.N.N

Molecular Formula

C10H28N9O13P3

Molecular Weight

575.30

References & Citations

[1]Ryosuke Nomura, et al. Azidothymidine-triphosphate Impairs Mitochondrial Dynamics by Disrupting the Quality Control System. Redox Biol. 2017 Oct;13:407-417.|[2]Takeya Sato, et al. Engineered Human tmpk/AZT as a Novel Enzyme/Prodrug Axis for Suicide Gene Therapy. Mol Ther. 2007 May;15 (5) :962-70.|[3]K Y Hostetler, et al. Enhanced Oral Absorption and Antiviral Activity of 1-O-octadecyl-sn-glycero-3-phospho-acyclovir and Related Compounds in Hepatitis B Virus Infection, in Vitro. Biochem Pharmacol. 1997 Jun 15;53 (12) :1815-22.