Methoctramine (tetrahydrochloride)

Methoctramine tetrahydrochloride is a potent and cardioselectivity antagonist of M2 muscarinic receptor. Methoctramine tetrahydrochloride can inhibit Muscarine (HY-121404) -induced bradycardia in vivo. Methoctramine tetrahydrochloride can be used in the study of cardiovascular diseases[1][2][3].

Product Specifications

CAS Number

[104807-46-7]

UNSPSC

12352005

Target

MAChR

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Purity

97.0

Solubility

H2O : 20 mg/mL (ultrasonic)

Smiles

COC1=C(C=CC=C1)CNCCCCCCNCCCCCCCCNCCCCCCNCC2=C(C=CC=C2)OC.Cl.Cl.Cl.Cl

Molecular Formula

C36H66Cl4N4O2

Molecular Weight

728.75

References & Citations

[1]Jaiswal N, et, al. Methoctramine, a cardioselective antagonist: muscarinic receptor mediating prostaglandin synthesis in isolated rabbit heart. Eur J Pharmacol. 1991 Jan 3;192 (1) :63-70.|[2]Watson N, et, al. Actions of methoctramine, a muscarinic M2 receptor antagonist, on muscarinic and nicotinic cholinoceptors in guinea-pig airways in vivo and in vitro. Br J Pharmacol. 1992 Jan;105 (1) :107-12.|[3]Wess J, et, al. Methoctramine selectively blocks cardiac muscarinic M2 receptors in vivo. Naunyn Schmiedebergs Arch Pharmacol. 1988 Sep;338 (3) :246-9.