RP-69758

RP-69758 is a potent and selective non-peptide cholecystokinin-B (CCKB) /gastrin receptor antagonist. RP-69758 exhibits >200-fold selectivity for CCKB over CCKA receptors. RP-69758 antagonizes CCK-8-induced neuronal firing in rat hippocampal slices. RP-69758 inhibits Pentagastrin (HY-A0261) -induced gastric acid secretion in the rat. RP-69758 can be used for neurological disorders and gastrointestinal disease research[1].

Product Specifications

CAS Number

[138562-23-9]

UNSPSC

12352005

Target

Cholecystokinin Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease; Inflammation/Immunology

Smiles

O=C(CC1=CC=CC(NC(NCC(N(C2=CC=CC=C2)CC(N(C3=CC=CC=C3)C)=O)=O)=O)=C1)O

Molecular Formula

C26H26N4O5

Molecular Weight

474.51

References & Citations

[1]Bertrand P, et al. Pharmacological properties of ureido-acetamides, new potent and selective non-peptide CCKB/gastrin receptor antagonists. Eur J Pharmacol. 1994 Sep 12;262 (3) :233-45.