PACA

PACA is an enhancer of nerve growth factor-induced neurite outgrowth, enhancing nerve growth factor (NGF) -induced neurite outgrowth and attenuating 6-hydroxydopamine (6-OHDA) -induced toxicity by activating the Nrf2/HO-1 pathway. PACA has neuroprotective and neurogenic activities. PACA can be used to improve dopaminergic neuron loss and motor dysfunction in MPTP mouse models of Parkinson's disease and MPP+-induced neurons[1][2].

Product Specifications

CAS Number

[1431724-30-9]

UNSPSC

12352005

Target

Keap1-Nrf2; Reactive Oxygen Species (ROS)

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Neurological Disease

Smiles

O=C(/C=C/C1=CC=C(C(O)=C1)O)NCC#C

Molecular Formula

C12H11NO3

Molecular Weight

217.22

References & Citations

[1]Luo D, et al. N-Propargyl Caffeamide (PACA) Ameliorates Dopaminergic Neuronal Loss and Motor Dysfunctions in MPTP Mouse Model of Parkinson's Disease and in MPP+-Induced Neurons via Promoting the Conversion of proNGF to NGF. Mol Neurobiol. 2018 Mar;55 (3) :2258-2267.|[2]Yang C, et al. N-Propargyl Caffeate Amide (PACA) Potentiates Nerve Growth Factor (NGF) -Induced Neurite Outgrowth and Attenuates 6-Hydroxydopamine (6-OHDA) -Induced Toxicity by Activating the Nrf2/HO-1 Pathway. ACS Chem Neurosci. 2015 Sep 16;6 (9) :1560-9.