5-PAHSA (Standard)

5-PAHSA (Standard) is the analytical standard of 5-PAHSA. This product is intended for research and analytical applications. 5-PAHSA increases insulin sensitivity, and has orally active anti-inflammatory and neuroprotective effects in mice HFD-induced diabetes mice. 5-PAHSA can be used for research of neurological dysfunction in diabetics[1][2][3].

Product Specifications

CAS Number

[1481636-41-2]

UNSPSC

12352100

Target

Endogenous Metabolite; Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Metabolic Disease; Inflammation/Immunology; Neurological Disease

Smiles

OC(CCCC(CCCCCCCCCCCCC)OC(CCCCCCCCCCCCCCC)=O)=O

Molecular Formula

C34H66O4

Molecular Weight

538.89

References & Citations

[1]Wang JT, et al. A novel palmitic acid hydroxy stearic acid (5-PAHSA) plays a neuroprotective role by inhibiting phosphorylation of the m-TOR-ULK1 pathway and regulating autophagy. CNS Neurosci Ther. 2021 Apr;27 (4) :484-496.|[2]Paluchova V, et al. Lipokine 5-PAHSA Is Regulated by Adipose Triglyceride Lipase and Primes Adipocytes for De Novo Lipogenesis in Mice. Diabetes. 2020 Mar;69 (3) :300-312. |[3]Wang YM, et al. High Glucose Concentration Impairs 5-PAHSA Activity by Inhibiting AMP-Activated Protein Kinase Activation and Promoting Nuclear Factor-Kappa-B-Mediated Inflammation. Front Pharmacol. 2019 Jan 7;9:1491.