CFI-401870
CFI-401870 is an orally active threonine tyrosine kinase (TTK (Mps1) ) inhibitor with an IC50 of 3.1 nM. CFI-401870 exhibits IC50s against PLK4, KDR, AURKA and other kinases such as AURKB/INCENP were all greater than 1 μM.CFI-401870 inhibits the growth of various cancer cells, causing chromosome lag, an increase in aneuploidy and cell cycle arrest. CFI-401870 can be used for the study of cancers such as colon cancer[1].
Product Specifications
CAS Number
1430741-35-7
UNSPSC
12352005
Target
DNA/RNA Synthesis; Mps1
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O[C@@H]1C[C@H](CC[C@@H]2C1)N2C3=CC=C(C=C3)C4=NNC5=C4C=C(C=C5)C(N[C@H](C6CC6)C7=NC=CC=C7)=O
Molecular Formula
C30H31N5O2
Molecular Weight
493.60
References & Citations
[1]Liu Y, et al. The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3- (4- (heterocyclyl) phenyl) -1H-indazole-5-carboxamides as Anticancer Agents. J Med Chem. 2015 Apr 23;58 (8) :3366-92.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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