SR-4554
SR-4554 is a probe for the measurement of tumor hypoxia. SR-4554 undergoes enzymatic single-electron reduction reactions within hypoxic cells. SR-4554 determines the 19F retention index for four commonly used mouse tumors (EMT6, SCCVII, KILT and RIF-I) through 19F MRS technique. SR-4554 can used to detect tumor Hypoxia noninvasively by 19F magnetic resonance spectroscopy (19F MRS) [1].
Product Specifications
CAS Number
[167648-73-9]
UNSPSC
12352005
Target
Biochemical Assay Reagents
Related Pathways
Others
Field of Research
Cancer
Smiles
O=C(NCC(O)C(F)(F)F)CN1C=CN=C1[N+]([O-])=O
Molecular Formula
C8H9F3N4O4
Molecular Weight
282.18
References & Citations
[1]Aboagye EO, et al. Preclinical evaluation of the fluorinated 2-nitroimidazole N- (2-hydroxy-3,3,3-trifluoropropyl) -2- (2-nitro-1-imidazolyl) acetamide (SR-4554) as a probe for the measurement of tumor hypoxia. Cancer Res. 1997 Aug 1;57 (15) :3314-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Curated Selection
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