Etilevodopa (hydrochloride) (Standard)

Etilevodopa (hydrochloride) (Standard) is the analytical standard of Etilevodopa (hydrochloride) . This product is intended for research and analytical applications. Etilevodopa (L-Dopa ethyl ester) hydrochloride, an ethyl-ester proagent of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa hydrochloride is used for the treatment of Parkinson disease (PD) . Levodopa is the direct precursor of dopamine and is a suitable proagent as it facilitates CNS penetration and delivers dopamine[1][2][3].

Product Specifications

CAS Number

[39740-30-2]

Product Name Alternative

L-DOPA ethyl ester (hydrochloride) (Standard) ; Levodopa ethyl ester (hydrochloride) (Standard)

UNSPSC

12352005

Target

Dopamine Receptor; Drug Metabolite; Reference Standards

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

N[C@@H](CC1=CC=C(O)C(O)=C1)C(OCC)=O.[H]Cl

Molecular Formula

C11H16ClNO4

Molecular Weight

261.70

References & Citations

[1]Blindauer K, et al. A randomized controlled trial of etilevodopa in patients with Parkinson disease who have motor fluctuations. Arch Neurol. 2006 Feb;63 (2) :210-6.|[2]Djaldetti R, et al. Pharmacokinetics of etilevodopa compared to levodopa in patients with Parkinson's disease: an open-label, randomized, crossover study. Clin Neuropharmacol. 2003 Nov-Dec;26 (6) :322-6.|[3]Haddad F, et al. Dopamine and Levodopa Prodrugs for the Treatment of Parkinson's Disease. Molecules. 2017 Dec 25;23 (1) . pii: E40.