LQFM030
LQFM030 is a novel small molecule MDM2 inhibitor. LQFM030 exhibits concentration dependent cytotoxicity in K562 cells (IC50 = 0.28 mM) . LQFM030 induces cell apoptosis through G0/G1 phase cell cycle arrest and increased Caspase activity. LQFM030 downregulates the mRNA expression of MDM2, MDMX, p73, MYC, and NF-κB. LQFM030 is commonly used in research on cancers such as leukemia[1].
Product Specifications
CAS Number
2180931-49-9
UNSPSC
12352005
Target
Apoptosis; Caspase; c-Myc; MDM-2/p53; NF-κB
Related Pathways
Apoptosis; NF-κB
Field of Research
Cancer
Smiles
CC(N1CCN(CC2=CN(C3=CC=C(Cl)C=C3)N=C2)CC1)=O
Molecular Formula
C16H19ClN4O
Molecular Weight
318.80
References & Citations
[1]de Oliveira Ribeiro H, et al. Small-molecule MDM2 inhibitor LQFM030-induced apoptosis in p53-null K562 chronic myeloid leukemia cells. Fundam Clin Pharmacol. 2020 Aug;34 (4) :444-457.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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