VU6001192
VU6001192 is a potent and selective mGlu2 (metabotropic glutamate receptor 2) negative allosteric modulator. VU6001192 has potent inhibitory activity against the mGlu2 receptor (IC50 = 207 nM), but no activity against the mGlu3 receptor and the other 6 mGlu subtypes. VU6001192 can be used for the research of neurological disease, such as depression[1].
Product Specifications
CAS Number
1821325-29-4
UNSPSC
12352005
Target
MGluR
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C1C(C(N)=O)=CN(C2=CC=C(CN3C[C@H](O[C@H](C3)C)C)C=C21)C4=CC=C(C=C4)F
Molecular Formula
C23H24FN3O3
Molecular Weight
409.45
References & Citations
[1]Felts AS, et al. Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2. J Med Chem. 2015 Nov 25;58 (22) :9027-40.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR2
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