E17110
E17110 is a liver X receptor β (LXRβ) agonist with an EC50 of 0.72 μM. E17110 can increase the expression of ATP-binding cassette transporter A1 (ABCA1) and G1 (ABCG1) in RAW264.7 macrophages. E17110 also reduce cellular lipid accumulation and promoted cholesterol efflux. E17110 can be used for the research of cardiovascular disease, such as atherosclerosis[1].
Product Specifications
CAS Number
[1090785-30-0]
UNSPSC
12352005
Target
ATP-binding cassette (ABC) transporters; LXR
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=C(NCC1)N1C(C(C)OC(C2=C(C)C3=CC(F)=CC=C3O2)=O)=O
Molecular Formula
C16H15FN2O5
Molecular Weight
334.30
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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