UNC3133
UNC3133 (Compound 16) is a selective and orally active macrocyclic mer tyrosine kinase (MerTK) inhibitor with an IC50 of 8.1 nM. UNC3133 has certain selectivity towards the TAM family (Axl and Tyro3) (with a selectivity of approximately 7 times for Axl and about 10 times for Tyro3), and has similar inhibitory activity towards Flt3. UNC3133 exhibits anti-tumor and anti-infection activities[1].
Product Specifications
CAS Number
[2011034-35-6]
UNSPSC
12352005
Target
TAM Receptor
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Infection
Smiles
OC(CCCCCCCN1)CCCCN2C3=NC1=NC=C3C(C4=CC=C(C=C4)CN5CCN(CC5)C)=C2
Molecular Formula
C30H44N6O
Molecular Weight
504.71
References & Citations
[1]Wang X, et al. Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors. ACS Med Chem Lett. 2016 Sep 13;7 (12) :1044-1049.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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