C620-0696
C620-0696 is an inhibitor targeting the brom domain of BPTF, with a KD value of 35.5 μM. C620-0696 can exert cytotoxic effects on A549 and H358 cells, inhibiting the expression of c-Myc. C620-0696 inhibits cell migration and colony formation, and induces apoptosis and cell cycle arrest. C620-0696 can be used in the research of non-small cell lung cancer[1].
Product Specifications
CAS Number
[902156-98-3]
UNSPSC
12352005
Target
C-Myc; Epigenetic Reader Domain
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1C2=C(C3=C4C1=C(NCCCN(C)C)C=C(NCC5=CC=CO5)C4=NO3)C=CC=C2
Molecular Formula
C24H24N4O3
Molecular Weight
416.47
References & Citations
[1]Xu J, et al. Compound C620-0696, a new potent inhibitor targeting BPTF, the chromatin-remodeling factor in non-small-cell lung cancer. Frontiers of medicine. 2020 Feb;14 (1) :60-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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