CN009543V
CN009543V is an epidermal growth factor receptor (EGFR) agonist. CN009543V enhances tyrosine phosphorylation of EGFR at Tyr1068 and Tyr1173, thereby activating the MAPK/ERK cascade. CN009543V inhibits the activity of PTP-1B in MDA MB468 cells. CN009543V can be used in cancer research[1].
Product Specifications
CAS Number
375826-84-9
UNSPSC
12352005
Target
EGFR; ERK; p38 MAPK; Phosphatase
Related Pathways
JAK/STAT Signaling; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Concentration
10mM
Purity
99.37
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OC)C(CSC1=CC=C([N+]([O-])=O)C2=NON=C21)NC(C)=O
Molecular Formula
C12H12N4O6S
Molecular Weight
340.31
References & Citations
[1]Sakanyan V, et al. Screening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells. Sci Rep. 2014 Feb 5;4:3977.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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