Thymidine 3',5'-diphosphate (tetrasodium)

Thymidine 3',5'-diphosphate (Deoxythymidine 3′,5′-diphosphate) tetrasodium is a selective inhibitor of staphylococcal nuclease and tudor domain containing 1 (SND1, the MicroRNA regulatory complex RISC subunit) and [3,5-2H2] tyrosyl nuclease. Thymidine 3',5'-diphosphate tetrasodium has anti-tumor activity and can also be used as a catalyst in biochemical reactions[1][2].

Product Specifications

CAS Number

[118675-87-9]

Product Name Alternative

Deoxythymidine 3′,5′-diphosphate (tetrasodium) ; pdTp (tetrasodium)

UNSPSC

12352005

Target

Apoptosis; MicroRNA

Related Pathways

Apoptosis; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.75

Solubility

DMSO : 3.33 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C1NC(N([C@@H](C[C@@H]2OP(O[Na])(O[Na])=O)O[C@@H]2COP(O[Na])(O[Na])=O)C=C1C)=O

Molecular Formula

C10H12N2Na4O11P2

Molecular Weight

490.12

References & Citations

[1]Nidhi Jariwala, et al. Oncogenic Role of SND1 in Development and Progression of Hepatocellular Carcinoma. Cancer Res. 2017 Jun 15;77 (12) :3306-3316.|[2]Cohen J S, et al. Proton magnetic resonance studies of the tyrosine residues of staphylococcal nuclease using [3, 5-2H2] tyrosine[J]. Biochimica et Biophysica Acta (BBA) -Protein Structure, 1971, 236 (2) : 468-478.