(Z) -NMac1

(Z) -NMac1 is an Nm23-H1 activator found in Zingiber cassumunar Roxb. (Z) -NMac1 has dual anti-metastatic and anti-proliferative biological activities. (Z) -NMac1 selectively inhibits cancer cell proliferation under glucose starvation conditions by inhibiting mitochondrial complex I activity, leading to ATP depletion and mitochondrial dysfunction. (Z) -NMac1 can be used to study tumors with high oxidative phosphorylation, especially in the glucose-restricted tumor microenvironment[1].

Product Specifications

CAS Number

[1667730-59-7]

UNSPSC

12352005

Target

Mitochondrial Metabolism; Oxidative Phosphorylation

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

COC(C=C1/C=C\C2C(C3=CC(OC)=C(C=C3)OC)C=CCC2)=C(C=C1)OC

Molecular Formula

C24H28O4

Molecular Weight

380.48

References & Citations

[1]Kim B, et al. Nm23-H1 activator phenylbutenoid dimer exerts cytotoxic effects on metastatic breast cancer cells by inducing mitochondrial dysfunction only under glucose starvation. Sci Rep. 2021 Dec 7;11 (1) :23549.