(Z) -NMac1
(Z) -NMac1 is an Nm23-H1 activator found in Zingiber cassumunar Roxb. (Z) -NMac1 has dual anti-metastatic and anti-proliferative biological activities. (Z) -NMac1 selectively inhibits cancer cell proliferation under glucose starvation conditions by inhibiting mitochondrial complex I activity, leading to ATP depletion and mitochondrial dysfunction. (Z) -NMac1 can be used to study tumors with high oxidative phosphorylation, especially in the glucose-restricted tumor microenvironment[1].
Product Specifications
CAS Number
1667730-59-7
UNSPSC
12352005
Target
Mitochondrial Metabolism; Oxidative Phosphorylation
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
COC(C=C1/C=C\C2C(C3=CC(OC)=C(C=C3)OC)C=CCC2)=C(C=C1)OC
Molecular Formula
C24H28O4
Molecular Weight
380.48
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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