(E) -FOBISIN101
(E) -FOBISIN101 is a 14-3-3 protein inhibitor (14-3-3γ IC50 = 16.4 μM; 14-3-3ζ IC50 = 9.3 μM) . (E) -FOBISIN101 inhibits the binding of 14-3-3 with Raf-1 and proline-rich AKT substrate, and neutralizes the ability of 14-3-3 to activate exoenzyme S ADP-ribosyltransferase. (E) -FOBISIN101 can be used for 14-3-3-mediated cancer research[1].
Product Specifications
CAS Number
1370281-06-3
UNSPSC
12352005
Target
Ser/Thr Protease
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Purity
95.63
Smiles
O=C(O[Na])C(C=C1)=CC=C1/N=N/C2=C(COP(O[Na])(O[Na])=O)C(C=O)=C(C(C)=N2)O
Molecular Formula
C15H11N3Na3O8P
Molecular Weight
461.21
References & Citations
[1]Zhao J, et al. Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor. Proc Natl Acad Sci U S A. 2011 Sep 27;108 (39) :16212-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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