Rev1-CT/RIR PPI-IN-1
Rev1-CT/RIR PPI-IN-1 (Compound 1) is a thiophene-based compound. Rev1-CT/RIR PPI-IN-1 can specifically disrupt the protein-protein interaction between Rev1-CT and RIR, with an IC50 value of 2.5 µM. Rev1-CT/RIR PPI-IN-1 can enhance chemosensitivity and reduce the mutation rate in Cisplatin (HY-17394) -sensitive HT-1080 cells. Rev1-CT/RIR PPI-IN-1 can be used for tumor research[1].
Product Specifications
CAS Number
[908510-73-6]
UNSPSC
12352005
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C(C1CCN(C(C)=O)CC1)NC2=C(C(NC3CC3)=O)C(CCC(C)C4)=C4S2
Molecular Formula
C21H29N3O3S
Molecular Weight
403.54
References & Citations
[1]Ozen Z, et al. Small molecule scaffolds that disrupt the Rev1-CT/RIR protein-protein interaction. Bioorg Med Chem. 2018 Aug 7;26 (14) :4301-4309.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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