6-MOMIPP

6-MOMIPP is a brain-penetrant microtubule disruptor that targets the colchicine site on β-tubulin. 6-MOMIPP can induce mitotic arrest and cell apoptosis. 6-MOMIPP has broad activity against the viability of multiple glioblastoma, melanoma and lung carcinoma cell lines. 6-MOMIPP can be used for the research of cancer[1].

Product Specifications

CAS Number

[1961272-45-6]

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Smiles

O=C(C1=CC=NC=C1)/C=C/C2=C(C)NC3=C2C=CC(OC)=C3

Molecular Formula

C18H16N2O2

Molecular Weight

292.33

References & Citations

[1]Du S, et al. 6-MOMIPP, a novel brain-penetrant anti-mitotic indolyl-chalcone, inhibits glioblastoma growth and viability. Cancer Chemother Pharmacol. 2019 Feb;83 (2) :237-254.