BMS-279700
BMS-279700 is an orally active Src-family kinase p56Lck inhibitor. BMS-279700 can block the production of proinflammatory cytokines (IL-2 and TNFα) . BMS-279700 can inhibit T cell proliferation. BMS-279700 can be used for the researches of inflammation and immunology[1].
Product Specifications
CAS Number
240814-54-4
UNSPSC
12352005
Target
Interleukin Related; Src; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; Protein Tyrosine Kinase/RTK
Field of Research
Inflammation/Immunology
Smiles
C[C@H](NCC1)CN1C2=CC=C3C(N4C(C(NC5=C(C=CC=C5Cl)C)=N3)=CN=C4)=N2
Molecular Formula
C21H22ClN7
Molecular Weight
407.90
References & Citations
[1]Chen P, et al. Imidazoquinoxaline Src-family kinase p56Lck inhibitors: SAR, QSAR, and the discovery of (S) -N- (2-chloro-6-methylphenyl) -2- (3-methyl-1-piperazinyl) imidazo- [1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a potent and orally active inhibitor with excellent in vivo antiinflammatory activity. J Med Chem. 2004 Aug 26;47 (18) :4517-29.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-12; Lck
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