A-134974

A-134974 is a novel, high-selectivity adenosine kinase (IC50 = 60 pM) inhibitor. A-134974 enhances endogenous adenosine signaling in the spinal cord, effectively alleviates neuropathic pain, and does not cause movement disorders. A-134974 can be used for the study of neuropathic pain[1].

Product Specifications

CAS Number

186141-75-3

UNSPSC

12352005

Target

Adenosine Kinase

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O[C@H]1[C@@H](C[C@@H]([C@H]1O)N)N2C3=NC=NC(N)=C3C(I)=C2

Molecular Formula

C11H14IN5O2

Molecular Weight

375.17

References & Citations

[1]McGaraughty S, et al. Effects of A-134974, a novel adenosine kinase inhibitor, on carrageenan-induced inflammatory hyperalgesia and locomotor activity in rats: evaluation of the sites of action. J Pharmacol Exp Ther. 2001 Feb;296 (2) :501-9. |[2]Zhu CZ, et al. A-134974: a novel adenosine kinase inhibitor, relieves tactile allodynia via spinal sites of action in peripheral nerve injured rats. Brain Res. 2001 Jun 29;905 (1-2) :104-10.