BB-3497

BB-3497 is a potent, orally active and selective peptide deformylase (PDF) inhibitor. BB-3497 is highly selective for PDF (IC50 = 7 nM for E. coli PDF.Ni) over the other mammalian metalloenzymes (MMP-1/2/3/7 and enkephalinase) . BB-3497 exhibits potent activity against gram-positive bacteria and some gram-negative pathogens. BB-3497 protects mice from infection in systemic models of Staphylococeus aureus. BB-3497 can be used for anti-bacterial infection research[1].

Product Specifications

CAS Number

235784-88-0

UNSPSC

12352211

Target

Antibiotic

Related Pathways

Anti-infection

Field of Research

Infection; Others

Smiles

CCCC[C@@H](C(N[C@@H](C(C)(C)C)C(N(C)C)=O)=O)CN(O)C=O

Molecular Formula

C16H31N3O4

Molecular Weight

329.44

References & Citations

[1]Clements JM, et al. Antibiotic activity and characterization of BB-3497, a novel peptide deformylase inhibitor. Antimicrob Agents Chemother. 2001 Feb;45 (2) :563-70.