AL-12180
AL-12180 is a potent and selective FP-receptor agonist with a Ki of 143 nM. AL-12180 stimulates the mobilization of intracellular Ca2+ in h-TM and h-CM cells with EC50s of 111 and 11 nM, respectively[1].
Product Specifications
CAS Number
[748816-43-5]
UNSPSC
12352005
Target
Prostaglandin Receptor
Related Pathways
GPCR/G Protein
Field of Research
Endocrinology
Smiles
O=C(CC/C=C\CC[C@@H]1[C@H](OC[C@@H]1O)/C=C/[C@H](COC2=CC=CC(Cl)=C2)O)O
Molecular Formula
C21H27ClO6
Molecular Weight
410.89
References & Citations
[1]Sharif NA, et al. Preclinical pharmacology of AL-12182, a new ocular hypotensive 11-oxa prostaglandin analog. J Ocul Pharmacol Ther. 2006 Oct;22 (5) :291-309.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Curated Selection
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