WAY-123783

WAY-123783 is a potent, selective and orally active sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor producing activity after metabolism. WAY-123783 can increase the excretion of sugar in urine and at the same time lower the blood sugar level in db/db mice (ED50 = 9.85 mg/kg) . WAY-123783 can be used for the research of metabolic disease, such as diabetes[1][2].

Product Specifications

CAS Number

[152595-59-0]

UNSPSC

12352005

Target

SGLT

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Smiles

O=C1NNC(C(F)(F)F)=C1CC2=CC=C(C=C2)SC

Molecular Formula

C12H11F3N2OS

Molecular Weight

288.29

References & Citations

[1]Ohsumi K, Matsueda H, Hatanaka T, Hirama R, Umemura T, Oonuki A, Ishida N, Kageyama Y, Maezono K, Kondo N. Pyrazole-O-glucosides as novel Na (+) -glucose cotransporter (SGLT) inhibitors. Bioorg Med Chem Lett. 2003 Jul 21;13 (14) :2269-72.|[2]Kees KL, et al. New potent antihyperglycemic agents in db/db mice: synthesis and structure-activity relationship studies of (4-substituted benzyl) (trifluoromethyl) pyrazoles and -pyrazolones. J Med Chem. 1996 Sep 27;39 (20) :3920-8.