WAY-123783
WAY-123783 is a potent, selective and orally active sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor producing activity after metabolism. WAY-123783 can increase the excretion of sugar in urine and at the same time lower the blood sugar level in db/db mice (ED50 = 9.85 mg/kg) . WAY-123783 can be used for the research of metabolic disease, such as diabetes[1][2].
Product Specifications
CAS Number
152595-59-0
UNSPSC
12352005
Target
SGLT
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Smiles
O=C1NNC(C(F)(F)F)=C1CC2=CC=C(C=C2)SC
Molecular Formula
C12H11F3N2OS
Molecular Weight
288.29
References & Citations
[1]Ohsumi K, Matsueda H, Hatanaka T, Hirama R, Umemura T, Oonuki A, Ishida N, Kageyama Y, Maezono K, Kondo N. Pyrazole-O-glucosides as novel Na (+) -glucose cotransporter (SGLT) inhibitors. Bioorg Med Chem Lett. 2003 Jul 21;13 (14) :2269-72.|[2]Kees KL, et al. New potent antihyperglycemic agents in db/db mice: synthesis and structure-activity relationship studies of (4-substituted benzyl) (trifluoromethyl) pyrazoles and -pyrazolones. J Med Chem. 1996 Sep 27;39 (20) :3920-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SGLT2
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