TASP0315003
TASP0315003 is a glycine transporter 1 (GlyT1) inhibitor. TASP0315003 potentiates NMDA receptor function by increasing synaptic glycine levels. TASP0315003 can improve cognitive dysfunction and the negative symptoms of schizophrenia without having undesirable central nervous system side effects. TASP0315003 can be used for the research of neurological disease[1].
Product Specifications
CAS Number
[1007109-16-1]
UNSPSC
12352005
Target
GlyT
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C(C1=NC=CC(C(F)(F)F)=C1Cl)NC(C2=CC=CC(C3=CN(CC)N=C3)=C2)[C@H]4NCCCC4
Molecular Formula
C24H25ClF3N5O
Molecular Weight
491.94
References & Citations
[1]Chaki S, et al. Efficacy of a glycine transporter 1 inhibitor TASP0315003 in animal models of cognitive dysfunction and negative symptoms of schizophrenia. Psychopharmacology (Berl) . 2015 Aug;232 (15) :2849-61.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GlyT1
Curated Selection
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