Dihydrochalcone
Dihydrochalcone (3-Phenylpropiophenone) is a BBB-penatrable Aβ aggregation inhibitor. Dihydrochalcone destabilizes Aβ17-42 protofibrils by disrupting the β-sheet of β1 region. Dihydrochalcone destabilizes both U-shaped Aβ40/Aβ42 protofibrils and S-shaped Aβ42 protofibrils by binding to the protofibril cavity. Dihydrochalcone is the main component of daemonorops draco tree[1].
Product Specifications
CAS Number
1083-30-3
Product Name Alternative
3-Phenylpropiophenone; β-Phenylpropiophenone
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Amyloid-β
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Purity
99.87
Smiles
O=C(CCC1=CC=CC=C1)C2=CC=CC=C2
Molecular Formula
C15H14O
Molecular Weight
210.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Jin Y, et al. Dihydrochalcone molecules destabilize Alzheimer's amyloid-β protofibrils through binding to the protofibril cavity. Phys Chem Chem Phys. 2018 Jun 27;20 (25) :17208-17217.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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