Dihydrochalcone

Dihydrochalcone (3-Phenylpropiophenone) is a BBB-penatrable Aβ aggregation inhibitor. Dihydrochalcone destabilizes Aβ17-42 protofibrils by disrupting the β-sheet of β1 region. Dihydrochalcone destabilizes both U-shaped Aβ40/Aβ42 protofibrils and S-shaped Aβ42 protofibrils by binding to the protofibril cavity. Dihydrochalcone is the main component of daemonorops draco tree[1].

Product Specifications

CAS Number

[1083-30-3]

Product Name Alternative

3-Phenylpropiophenone; β-Phenylpropiophenone

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Amyloid-β

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Purity

99.87

Smiles

O=C(CCC1=CC=CC=C1)C2=CC=CC=C2

Molecular Formula

C15H14O

Molecular Weight

210.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Jin Y, et al. Dihydrochalcone molecules destabilize Alzheimer's amyloid-β protofibrils through binding to the protofibril cavity. Phys Chem Chem Phys. 2018 Jun 27;20 (25) :17208-17217.