FD-895
FD-895 is a spliceosome modulator derived from a polyketide natural product, targeting the SF3b subunit of the spliceosome. FD-895 possesses core biological activities for regulating RNA splicing (intron retention, alternative splicing) and inducing apoptosis of cancer cells. FD-895 can be used for the research of cancer, such as chronic lymphocytic leukemia (CLL) [1].
Product Specifications
CAS Number
[147025-57-8]
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC[C@H](OC)[C@H]([C@]1([H])[C@]([C@H](O)[C@H](C)/C=C/C=C([C@@H](O2)[C@H](/C=C/[C@@H]([C@](O)(CC[C@@H](O)CC2=O)C)OC(C)=O)C)\C)([H])O1)C
Molecular Formula
C31H50O9
Molecular Weight
566.72
References & Citations
[1]Dhar S, et al. A Carbohydrate-Derived Splice Modulator. J Am Chem Soc. 2016 Apr 20;138 (15) :5063-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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