ARRY-371797

ARRY-371797 is a potent and orally active p38α MAPK and BChE inhibitor with IC50 values of 12.0, 0.13, > 100 µM for p38α MAP, hBChE, hAChE, respectively. ARRY-371797 has the potential for the research of Alzheimer’s disease[1].

Product Specifications

CAS Number

[3077831-12-7]

UNSPSC

12352100

Target

Cholinesterase (ChE) ; p38 MAPK

Related Pathways

MAPK/ERK Pathway; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(C1=CC2=NN(CC(C)C)C=C2C=C1OC3=CC=C(F)C=C3F)NCCN(C)C

Molecular Formula

C22H26F2N4O2

Molecular Weight

416.46

References & Citations

[1]Ferjančič Benetik S, et al. Targeting Neuroinflammation and Cognitive Decline: First-in-Class Dual Butyrylcholinesterase and p38α Mitogen-Activated Protein Kinase Inhibitors. J Med Chem. 2025 Aug 28;68 (16) :17378-17411.