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ST-539

ST-539 is the inhibitor for deubiquitinase USP30 with IC50 of 0.37 μM. ST-539 promotes the ubiquitination of mitochondrial proteins, and induces mitochondrial autophagy, thereby regulating mitochondrial homeostasis. ST-539 can be used in research of neurodegenerative diseases[1].

Product Specifications

CAS Number

1040754-67-3

UNSPSC

12352005

Target

Autophagy; Deubiquitinase

Related Pathways

Autophagy; Cell Cycle/DNA Damage

Field of Research

Neurological Disease

Smiles

O=C(NC1=C2C=CC=C(S(=O)(NC(C)(C)C)=O)C2=CC=C1)C(NC(C3=CC=CC=C3)=O)CC4=CC=CC=C4

Molecular Formula

C30H31N3O4S

Molecular Weight

529.65

References & Citations

[1]Yang P, et al., Mitophagy in Neurodegenerative Diseases: Mechanisms of Action and the Advances of Drug Discovery. J Med Chem. 2025 Feb 27;68 (4) :3970-3994.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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