ST-539
ST-539 is the inhibitor for deubiquitinase USP30 with IC50 of 0.37 μM. ST-539 promotes the ubiquitination of mitochondrial proteins, and induces mitochondrial autophagy, thereby regulating mitochondrial homeostasis. ST-539 can be used in research of neurodegenerative diseases[1].
Product Specifications
CAS Number
1040754-67-3
UNSPSC
12352005
Target
Autophagy; Deubiquitinase
Related Pathways
Autophagy; Cell Cycle/DNA Damage
Field of Research
Neurological Disease
Smiles
O=C(NC1=C2C=CC=C(S(=O)(NC(C)(C)C)=O)C2=CC=C1)C(NC(C3=CC=CC=C3)=O)CC4=CC=CC=C4
Molecular Formula
C30H31N3O4S
Molecular Weight
529.65
References & Citations
[1]Yang P, et al., Mitophagy in Neurodegenerative Diseases: Mechanisms of Action and the Advances of Drug Discovery. J Med Chem. 2025 Feb 27;68 (4) :3970-3994.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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