Selpercatinib-13C, d3
Selpercatinib-13C, d3 (LOXO-292-13C, d3) is 13C labeled Selpercatinib. Selpercatinib (LOXO-292) is a potent, selective RET kinase inhibitor with IC50 values of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively. Selpercatinib has anticancer activity[1][2].
Product Specifications
Product Name Alternative
LOXO-292-13C, d3
UNSPSC
12352005
Target
Isotope-Labeled Compounds
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
N#CC1=C2C(C3=CC=C(N4CC(C5)N(CC6=CC=C(O[13C]([2H])([2H])[2H])N=C6)C5C4)N=C3)=CC(OCC(C)(O)C)=CN2N=C1
Molecular Formula
C28 13CH28D3N7O3
Molecular Weight
529.61
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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