Selpercatinib-13C, d3

Selpercatinib-13C, d3 (LOXO-292-13C, d3) is 13C labeled Selpercatinib. Selpercatinib (LOXO-292) is a potent, selective RET kinase inhibitor with IC50 values of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively. Selpercatinib has anticancer activity[1][2].

Product Specifications

Product Name Alternative

LOXO-292-13C, d3

UNSPSC

12352005

Target

Isotope-Labeled Compounds

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

N#CC1=C2C(C3=CC=C(N4CC(C5)N(CC6=CC=C(O[13C]([2H])([2H])[2H])N=C6)C5C4)N=C3)=CC(OCC(C)(O)C)=CN2N=C1

Molecular Formula

C28 13CH28D3N7O3

Molecular Weight

529.61

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Curated Selection

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