BC-1485
BC-1485 is a small molecule inhibitor of Fibrosis-inducing E3 ligase 1 (FIEL1) . BC-1485 protects PIAS4 from ubiquitin-mediated degradation. BC-1485 decreases α-SMA, BAL and CXCL1. BC-1485 ameliorates fibrotic lung injury in murine models[1][2].
Product Specifications
CAS Number
[2035085-19-7]
UNSPSC
12352005
Target
CXCR
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Field of Research
Others
Smiles
O=C(NC(C)C(N(C)C)=O)C1=CC=C(NS(=O)(C2=CC=C(N3)C(NC3=O)=C2)=O)C=C1
Molecular Formula
C19H21N5O5S
Molecular Weight
431.47
References & Citations
[1]Lear T, et al. Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4. J Exp Med. 2016 May 30;213 (6) :1029-46.|[2]Lear T, et al. Therapeutic targets in fibrotic pathways. Cytokine. 2016 Dec;88:193-195.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CXCR1
Available Sizes
Curated Selection
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