BC-1485
BC-1485 is a small molecule inhibitor of Fibrosis-inducing E3 ligase 1 (FIEL1) . BC-1485 protects PIAS4 from ubiquitin-mediated degradation. BC-1485 decreases α-SMA, BAL and CXCL1. BC-1485 ameliorates fibrotic lung injury in murine models[1][2].
Product Specifications
CAS Number
2035085-19-7
UNSPSC
12352005
Target
CXCR
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Field of Research
Others
Smiles
O=C(NC(C)C(N(C)C)=O)C1=CC=C(NS(=O)(C2=CC=C(N3)C(NC3=O)=C2)=O)C=C1
Molecular Formula
C19H21N5O5S
Molecular Weight
431.47
References & Citations
[1]Lear T, et al. Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4. J Exp Med. 2016 May 30;213 (6) :1029-46.|[2]Lear T, et al. Therapeutic targets in fibrotic pathways. Cytokine. 2016 Dec;88:193-195.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CXCR1
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS1456474-01 0.02 mg (E-Coli)
Recombinant Human Probable exonuclease mut-7 homolog, isoform 5 (EXD3)
Sign In for Pricing
View Details MBS1456474-02 0.1 mg (E-Coli)
Recombinant Human Probable exonuclease mut-7 homolog, isoform 5 (EXD3)
Sign In for Pricing
View Details MBS1456474-03 0.02 mg (Yeast)
Recombinant Human Probable exonuclease mut-7 homolog, isoform 5 (EXD3)
Sign In for Pricing
View Details MBS1456474-04 0.1 mg (Yeast)
Recombinant Human Probable exonuclease mut-7 homolog, isoform 5 (EXD3)
Sign In for Pricing
View Details MBS1456474-05 0.02 mg (Baculovirus)
Recombinant Human Probable exonuclease mut-7 homolog, isoform 5 (EXD3)
Sign In for Pricing
View Details MBS1456474-06 0.02 mg (Mammalian-Cell)
Recombinant Human Probable exonuclease mut-7 homolog, isoform 5 (EXD3)
Sign In for Pricing
View Details