SRI 31215
SRI 31215 is a Matriptase/Hepsin/hepatocyte growth factor activator (HGFA) triplex inhibitor and mimics the activity of HAI-1/2 (endogenous inhibitors of HGF activation) . SRI 31215 has potent inhibitory activity against matriptase, hepsin and HGFA with IC50 values of 0.69 μM, 0.65 μM and 0.30 μM, respectively. SRI 31215 can be used for the research of cancer[1].
Product Specifications
CAS Number
[1832686-43-7]
UNSPSC
12352005
Target
C-Met/HGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
N=C(C1=CC=CC(N2CC(C)CN(CC3CCN(CC4=CC=CC=C4)CC3)C2=O)=C1)N
Molecular Formula
C25H33N5O
Molecular Weight
419.56
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Mol Cancer Ther. 2023 Jun 1;22 (6) :765-777.|Biomedicines. 2025 Mar 28;13 (4) :811.|Int J Mol Sci. 2025 Mar 5;26 (5) :2308.
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