Acetyl coenzyme A-d3

Acetyl coenzyme A-d3 (Acetyl-CoA-d3) is the deuterium labeled Acetyl coenzyme A (HY-114293) . Acetyl-coenzyme A (Acetyl-CoA) is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A is also a key precursor of lipid synthesis[1][2][3][4].

Product Specifications

CAS Number

[121443-44-5]

Product Name Alternative

Acetyl-CoA-d3

UNSPSC

12352005

Target

Autophagy; Endogenous Metabolite; Isotope-Labeled Compounds; Oxidative Phosphorylation

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Others

Field of Research

Metabolic Disease; Cardiovascular Disease

Smiles

CC([C@H](C(NCCC(NCCSC(C([2H])([2H])[2H])=O)=O)=O)O)(C)COP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@H](O)[C@@H]1OP(O)(O)=O)(O)=O)(O)=O

Molecular Formula

C23H35D3N7O17P3S

Molecular Weight

812.59

References & Citations

[1]Choudhary C, et al. The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol. 2014 Aug;15 (8) :536-50. |[2]Mariño G, et al. Regulation of autophagy by cytosolic acetyl-coenzyme A. Mol Cell. 2014 Mar 6;53 (5) :710-25. |[3]Zhu H, et al. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest. 2007 Jul;117 (7) :1782-93.|[4]Pietrocola F, et al. Acetyl coenzyme A: a central metabolite and second messenger. Cell Metab. 2015 Jun 2;21 (6) :805-21.