L-163958

L-163958 is an efficient, orally active, balanced angiotensin II receptor (AII receptor) antagonist. L-163958 has balanced high affinity for AT1 and AT2, with its IC50 values being 0.16, 0.12, 0.50, and 0.64 nM in rabbit aorta (AT1), rat midbrain (AT2), human adrenal gland (AT1), and human adrenal gland (AT2), respectively. L-163958 has a strong inhibitory effect on the pressor activity in rats. L-163958 can be used for the study of hypertension and related cardiovascular diseases[1].

Product Specifications

CAS Number

[168473-51-6]

UNSPSC

12352005

Target

Angiotensin Receptor

Related Pathways

GPCR/G Protein

Field of Research

Cardiovascular Disease

Smiles

O=C(OC(C)(C)C)NS(=O)(C1=CC=CC=C1C2=CC=C(CN3C(CC)=NN(C4=CC(NC(CCCC)=O)=CC=C4Br)C3=O)C(F)=C2)=O

Molecular Formula

C33H37BrFN5O6S

Molecular Weight

730.64

References & Citations

[1]Chang LL, et al. Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes. J Med Chem. 1995 Sep 15;38 (19) :3741-58.