LY3295668 (erbumine)
LY3295668 (AK-01) erbumine is a highly specific and orally active inhibitor of Aurora-A kinase with a Ki values for AurA and AurB of 0.8 nM and 1038 nM respectively. LY3295668 erbumine can effectively inhibit the autophosphorylation of AurA, induce mitotic arrest and apoptosis. LY3295668 erbumine avoids the formation of polyploids related to AurB inhibition. LY3295668 erbumine can be used for the study of small cell lung cancer[1][2].
Product Specifications
CAS Number
1919888-07-5
Product Name Alternative
AK-01 (erbumine)
UNSPSC
12352005
Target
Apoptosis; Aurora Kinase
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
CC(C)(N)C.OC([C@]1(C[C@H](N(CC1)CC2=C(C(Cl)=CC=C2)F)C)CC3=C(F)C=CC(NC4=NNC(C)=C4)=N3)=O
Molecular Formula
C28H37ClF2N6O2
Molecular Weight
563.08
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora A; Aurora B
Frequently Asked Questions
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