ODS-2004436
ODS-2004436 is a small molecule radiotracer that uses positron emission tomography (PET) imaging to measure the activity of the epidermal growth factor receptor (EGFR) in tumors. ODS-2004436 labeled with the radioactive isotope fluorine-18 shows significantly higher uptake in the xenograft models of lung cancer with EGFR mutations compared to the wild-type models, and could be used to distinguish the mutation status. ODS-2004436 can be used to identify EGFR-positive tumors and predict their response to certain reagent treatments, especially for non-small cell lung cancer (NSCLC) [1].
Product Specifications
CAS Number
[2130982-18-0]
UNSPSC
12352005
Target
EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
ClC1=CC(NC2=NC=NC3=CC(OCC[18F])=C(OCCCNC([C@@H](C(C)C)N4)=O)C=C23)=C(CC4=O)C=C1
Molecular Formula
C26H29ClFN5O4
Molecular Weight
528.99
References & Citations
[1]Waaijer SJ, et al. Molecular imaging in cancer drug development. Journal of Nuclear Medicine. 2018 May 1;59 (5) :726-32.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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