TAK-070 (hydrochloride hydrate)
TAK-070 hydrochloride hydrate is a noncompetitive and orally active BACE1 inhibitor (IC50 = 3.15 μM) . TAK-070 hydrochloride hydrate can be used for research of Alzheimer’s disease (AD) . TAK-070 hydrochloride hydrate inhibits brain levels of soluble Aβ, and improves cognitive impairments in AD model[1].
Product Specifications
UNSPSC
12352005
Target
Amyloid-β; Beta-secretase
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
CN(C)CC[C@H]1CC2=C(C=C(OCC3=CC=C(C4=CC=CC=C4)C=C3)C=C2)CC1.Cl.O
Molecular Formula
C27H34ClNO2
Molecular Weight
440.02
References & Citations
[1]Fukumoto H, et al. A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease. J Neurosci. 2010 Aug 18;30 (33) :11157-66.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-114234/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BACE1
CAS Number
[365276-12-6]
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