VTP50469 (Standard)
VTP50469 (Standard) is the analytical standard of VTP50469. This product is intended for research and analytical applications. VTP50469 is a potent, highly selective and orally active Menin-MLL interaction inhibitor with a Ki of 104 pM. VTP50469 has potently anti-leukemia activity[1][2].
Product Specifications
CAS Number
[2169916-18-9]
UNSPSC
12352005
Target
Apoptosis; Epigenetic Reader Domain; Reference Standards
Related Pathways
Apoptosis; Epigenetics; Others
Field of Research
Cancer
Purity
96.31
Smiles
O=C(N(C(C)C)C(C)C)C1=CC(F)=CC=C1OC2=CN=CN=C2N3CC4(CCN(C[C@H]5CC[C@H](NS(=O)(C)=O)CC5)CC4)C3
Molecular Formula
C32H47FN6O4S
Molecular Weight
630.82
References & Citations
[1]Krivtsov AV, et al. A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia. Cancer Cell. 2019 Dec 9;36 (6) :660-673.e11.|[2]Andrei V. Krivtsov, et al. Abstract 4958: VTP50469 is a novel, orally available menin-MLL1 inhibitor effective against MLL-rearranged and NPM1-mutant leukemia. Cancer Resceach. July 2018.Volume 78, Issue 13 Supplement.
Shipping Conditions
Blue Ice
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS7193575 Inquire
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) ADF1 Polyclonal Antibody
Ask
View Details ![Rabbit Polyclonal MP1/MAP2K1IP1 Antibody [PerCP]](https://cdn.genprice.uk/genprice/uk/genprice4.webp)
D1075-02F 100 µL
DARPP32, phosphorylated (Thr75) (Dopamine and cAMP-regulated Phosphoprotein, Protein phosphatase 1 regulatory subunit 1B, PP1R1B) discontinued. See D1075-02
Ask
View Details