NGD 98-2
NGD 98-2 is an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist
Product Specifications
CAS Number
[355836-54-3]
UNSPSC
12352005
Target
CRFR
Related Pathways
GPCR/G Protein
Field of Research
Neurological Disease
Smiles
CC1=C(C2=CC=C(OC(F)(F)F)C=C2OC)N=C(OC)C(NC(CC)CC)=N1
Molecular Formula
C19H24F3N3O3
Molecular Weight
399.41
References & Citations
[1]Hodgetts KJ, Ge P, Yoon T, De Lombaert S, Brodbeck R, Gulianello M, Kieltyka A, Horvath RF, Kehne JH, Krause JE, Maynard GD, Hoffman D, Lee Y, Fung L, Doller D. Discovery of N- (1-ethylpropyl) -[3-methoxy-5- (2-methoxy-4-trifluoromethoxyphenyl) -6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2) : an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist. J Med Chem. 2011 Jun 23;54 (12) :4187-206. doi: 10.1021/jm200365y. Epub 2011 May 27. PMID: 21618986.|[2]Million M, Zhao JF, Luckey A, Czimmer J, Maynard GD, Kehne J, Hoffman DC, Taché Y. The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats. PLoS One. 2013 Sep 6;8 (9) :e73749. doi: 10.1371/journal.pone.0073749. PMID: 24040053; PMCID: PMC3765344.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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