LY459477

LY459477 is a potent, selective and orally active metabotropic glutamate 2/3 receptor (mGluR2/3) agonist. LY459477 can effectively suppress Phencyclidine-evoked locomotor activity at doses that do not impair neuromuscular coordination. LY459477 can be used for the research of neurological disease[1].

Product Specifications

CAS Number

[635318-20-6]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

MGluR

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

OC([C@]1([C@@]2([H])[C@]([C@@H](C1)F)([H])[C@@H]2C(O)=O)N)=O

Molecular Formula

C8H10FNO4

Molecular Weight

203.17

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Monn JA, et al. Synthesis and pharmacological characterization of 4-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: identification of new potent and selective metabotropic glutamate 2/3 receptor agonists. J Med Chem. 2013 Jun 13;56 (11) :4442-55.