LY459477
LY459477 is a potent, selective and orally active metabotropic glutamate 2/3 receptor (mGluR2/3) agonist. LY459477 can effectively suppress Phencyclidine-evoked locomotor activity at doses that do not impair neuromuscular coordination. LY459477 can be used for the research of neurological disease[1].
Product Specifications
CAS Number
635318-20-6
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
MGluR
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
OC([C@]1([C@@]2([H])[C@]([C@@H](C1)F)([H])[C@@H]2C(O)=O)N)=O
Molecular Formula
C8H10FNO4
Molecular Weight
203.17
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Monn JA, et al. Synthesis and pharmacological characterization of 4-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: identification of new potent and selective metabotropic glutamate 2/3 receptor agonists. J Med Chem. 2013 Jun 13;56 (11) :4442-55.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Isoform
MGluR2; mGluR3
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