JNJ 40279486
JNJ 40279486 is a novel and highly selective histamine H4 receptor antagonist with a Ki of 9 nM. JNJ 40279486 can be used in the research of immune-driven inflammatory diseases[1].
Product Specifications
CAS Number
1002351-34-9
UNSPSC
12352005
Target
Histamine Receptor
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Field of Research
Inflammation/Immunology
Smiles
NC=1N=C2C(=C(N1)N3C[C@H](NC)CC3)OC=4C2=CC(Cl)=CN4
Molecular Formula
C14H15ClN6O
Molecular Weight
318.77
References & Citations
[1]Savall BM, et al. Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H₄ receptor antagonists. J Med Chem. 2014 Mar 27;57 (6) :2429-39.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H4 Receptor
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