PF-719

PF-719 is a selective inhibitor of Pyk2 (IC50: 17 nM) . PF-719 inhibits FAK activity (IC50: 469 nM) . PF-719 inhibits the kinase activities of Hck, Fyn, Lck, and Lyn in A20 B-lymphoma cells, with an IC50 of 6.7 μM for Lyn[1].

Product Specifications

CAS Number

[1404454-02-9]

UNSPSC

12352005

Target

FAK; Pyk2

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Purity

99.52

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1CC1)C2=CC=C(NC3=NC=C(C(F)(F)F)C(N[C@H]4[C@H](N(C)C)CCC4)=N3)C=C2

Molecular Formula

C22H27F3N6O

Molecular Weight

448.48

References & Citations

[1]Tse KW, et al. Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells. Cell Immunol. 2012 Jan-Feb;275 (1-2) :47-54.