Xestoquinone
Xestoquinone ((+) -Xestoquinone) is a Plasmodium falciparum protein kinase Pfnek-1 inhibitor (IC50=1.1 μM) . Xestoquinone is promising for research of antimalarial agents[1][2].
Product Specifications
CAS Number
[97743-96-9]
Product Name Alternative
(+) -Xestoquinone
UNSPSC
12352005
Target
Parasite
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
C[C@@]12C3=C(OC=C3CCC2)C(C4=CC(C(C=CC5=O)=O)=C5C=C41)=O
Molecular Formula
C20H14O4
Molecular Weight
318.32
References & Citations
[1]Harada N, et al. Total synthesis and absolute stereochemistry of (+) -xestoquinone and xestoquinol[J]. The Journal of Organic Chemistry, 1990, 55 (10) : 3158-3163.|[2]Laurent D, et al. Antimalarial potential of xestoquinone, a protein kinase inhibitor isolated from a Vanuatu marine sponge Xestospongia sp. Bioorg Med Chem. 2006 Jul 1;14 (13) :4477-82.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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